Association in a Chinese population of a genetic variation in the early B-cell factor 1 gene with coronary artery disease.

ABSTRACT:

Background

Early B-cell factor 1 (EBF1) is a transcription factor expressed primarily during early B cell development. Previous studies have shown EBF1 regulates blood glucose and lipid metabolism in mice with diabetes and central adiposity. Recently, a genetic variation (rs36071027) located in an EBF1 gene intron was associated with carotid artery intima-media thickness. However, whether this polymorphism is actually linked with coronary artery disease (CAD) and its severity remains unclear.

Methods

This study includes 293 CAD cases and 262 controls without CAD. All participants were devided into two groups based on their coronary angiography results. A polymerase chain reaction-ligase detection reaction was used to identify genotypes at rs36071027, and CAD patients were fu

SUBMITTER: Li Y 

PROVIDER: S-EPMC5301365 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature