Safety and improvement of movement function after stroke with atomoxetine: A pilot randomized trial.

ABSTRACT:

Background

Intensive, task-oriented motor training has been associated with neuroplastic reorganization and improved upper extremity movement function after stroke. However, to optimize such training for people with moderate-to-severe movement impairment, pharmacological modulation of neuroplasticity may be needed as an adjuvant intervention.

Objective

Evaluate safety, as well as improvement in movement function, associated with motor training paired with a drug to upregulate neuroplasticity after stroke.

Methods

In this double-blind, randomized, placebo-controlled study, 12 subjects with chronic stroke received either atomoxetine or placebo paired with motor training. Safety was assessed using vital signs. Upper extremity movement function was assessed using Fugl-Mey

SUBMITTER: Ward A 

PROVIDER: S-EPMC5302031 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature