CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.

ABSTRACT: Other than an association with HPV infection, little is known about the genetic alterations determining the development of penile cancer. Although penile cancer is rare in the developed world, it presents a significant burden in developing countries. Here, we report the findings of whole-exome sequencing (WES) to determine the somatic mutational landscape of penile cancer. WES was performed on penile cancer and matched germline DNA from 27 patients undergoing surgical resection. Targeted resequencing of candidate genes was performed in an independent 70 patient cohort. Mutation data were also integrated with DNA methylation and copy-number information from the same patients. We identified an HPV-associated APOBEC mutation signature and an NpCpG signature in HPV-negative disease. We also id

SUBMITTER: Feber A 

PROVIDER: S-EPMC5302160 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature