The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle.

ABSTRACT:

Background

The discovery of functional classes of long noncoding RNAs (lncRNAs) has expanded our understanding of the variety of RNA species that exist in cells. In the heart, lncRNAs have been implicated in the regulation of development, ischemic and dilated cardiomyopathy, and myocardial infarction. Nevertheless, there is a limited description of expression profiles for these transcripts in human subjects.

Methods and results

We obtained left ventricular tissue from human patients undergoing cardiac surgery and used RNA sequencing to describe an lncRNA profile. We then identified a list of lncRNAs that were differentially expressed between pairs of samples before and after the ischemic insult of cardiopulmonary bypass. The expression of some of these lncRNAs correlates wit

SUBMITTER: Saddic LA 

PROVIDER: S-EPMC5302288 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature