Anticholinergic burden and cognitive function in a large German cohort of hospitalized geriatric patients.

ABSTRACT:

Purpose

Previous studies suggest an association between use of anticholinergic drugs in elderly patients and cognitive impairment. However, there are still limited data on the association of anticholinergic drug use and cognitive impairment as well as contribution of individual drugs to anticholinergic load using large, well-documented patient cohorts treated in geriatric units from Europe.

Methods

We investigated 797,440 prescriptions to 89,579 hospitalized patients treated in geriatric units within the GiB-DAT database. Data of all patients discharged between 1 January 2013 and 30 June 2015 was included. The Anticholinergic Cognitive Burden (ACB) scale was used to classify anticholinergic drugs as definite (score 2 or 3) and possible anticholinergics (score 1). Cognitive f

SUBMITTER: Pfistermeister B 

PROVIDER: S-EPMC5302450 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature