Distinct antibody responses of patients with mild and severe leptospirosis determined by whole proteome microarray analysis.

ABSTRACT:

Background

Leptospirosis is an important zoonotic disease worldwide. Humans usually present a mild non-specific febrile illness, but a proportion of them develop more severe outcomes, such as multi-organ failure, lung hemorrhage and death. Such complications are thought to depend on several factors, including the host immunity. Protective immunity is associated with humoral immune response, but little is known about the immune response mounted during naturally-acquired Leptospira infection.

Methods and principal findings

Here, we used protein microarray chip to profile the antibody responses of patients with severe and mild leptospirosis against the complete Leptospira interrogans serovar Copenhageni predicted ORFeome. We discovered a limited number of immunodominant antigen

SUBMITTER: Lessa-Aquino C 

PROVIDER: S-EPMC5302828 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature