Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses.

ABSTRACT: While influenza virus diversity and antigenic drift have been well characterized on a global scale, the factors that influence the virus' rapid evolution within and between human hosts are less clear. Given the modest effectiveness of seasonal vaccination, vaccine-induced antibody responses could serve as a potent selective pressure for novel influenza variants at the individual or community level. We used next generation sequencing of patient-derived viruses from a randomized, placebo-controlled trial of vaccine efficacy to characterize the diversity of influenza A virus and to define the impact of vaccine-induced immunity on within-host populations. Importantly, this study design allowed us to isolate the impact of vaccination while still studying natural infection. We used pre-season he

SUBMITTER: Debbink K 

PROVIDER: S-EPMC5302840 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature