Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.

ABSTRACT: Understanding the complex interaction between growth factor and steroid hormone signaling pathways in breast cancer is key to identifying suitable therapeutic strategies to avoid progression and therapy resistance. The interaction between these two pathways is of paramount importance for the development of endocrine resistance. Nevertheless, the molecular mechanisms behind their crosstalk are still largely obscure. We previously reported that Memo is a small redox-active protein that controls heregulin-mediated migration of breast cancer cells. Here we report that Memo sits at the intersection between heregulin and estrogen signaling, and that Memo controls Estrogen Receptor alpha (ERα) sub-cellular localization, phosphorylation, and function downstream of heregulin and estrogen in breast

SUBMITTER: Frei A 

PROVIDER: S-EPMC5302904 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature