Procoagulant and immunogenic properties of melanoma exosomes, microvesicles and apoptotic vesicles.

ABSTRACT: Extracellular vesicles (EV) are lipid particles released from eukaryotic cells into the extracellular fluid. Depending on the cell type or mechanism of release, vesicles vary in form and function and exert distinct functions in coagulation and immunity. Tumor cells may constitutively shed vesicles known as exosomes or microvesicles (MV). Alternatively, apoptosis induces the release of apoptotic blebs or vesicles (ApoV) from the plasma membrane. EV have been implicated in thrombotic events (the second highest cause of death in cancer patients) and tumor vesicles contribute to the anti-cancer immune response. In this study, we utilized the well characterized B16 melanoma model to determine the molecular composition and procoagulant and immunogenic potential of exosomes, MV and ApoV. Distinct

SUBMITTER: Muhsin-Sharafaldine MR 

PROVIDER: S-EPMC5302914 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature