Association of the GLB1 rs4678680 genetic variant with risk of HBV-related hepatocellular carcinoma.

ABSTRACT: Accumulated evidences demonstrated that GLB1 is involved in cell senescence and cancer development. The GLB1 rs4678680 single nucleotide polymorphism (SNP) has been identified as a hepatocellular carcinoma (HCC) susceptibility polymorphism by a genome-wide association study in Korean population previously. However, little or nothing was known about its involvement and functional significance in hepatitis B viruses (HBV)-related HCC in Chinese. Therefore, we investigated the association between the GLB1 rs4678680 SNP and HBV-related HCC risk as well as its biological function in vivo. Genotypes were determined in two independent case-control sets from two medical centers of China. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression. The potential regul

SUBMITTER: Wang WT 

PROVIDER: S-EPMC5302931 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature