Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells.

ABSTRACT:

Background

Peritoneal metastasis consists of a highly complex series of steps, and the details of the underlying molecular mechanism remain largely unclear. In this study, the effects of tumor-derived exosomes (TEX) on the progression of gastric cancers were investigated in peritoneal metastasis.

Results

TEX were internalized in both mesothelial and gastric cancer cells in a cellular origin non-specific manner. Internalization of TEX into mesothelial cells promoted significant adhesion between mesothelial and gastric cancer cells, and TEX internalization into gastric cancer cells significantly promoted migratory ability, while internalization of mesothelial cell-derived exosomes did not. Expression of adhesion-related molecules, such as fibronectin 1 (FN1) and laminin gamma

SUBMITTER: Arita T 

PROVIDER: S-EPMC5302957 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature