Re-assessing gallium-67 as a therapeutic radionuclide.

ABSTRACT:

Introduction

Despite its desirable half-life and low energy Auger electrons that travel further than for other radionuclides, ⁶⁷Ga has been neglected as a therapeutic radionuclide. Here, ⁶⁷Ga is compared with Auger electron emitter ¹¹¹In as a potential therapeutic radionuclide.

Methods

Plasmid pBR322 studies allowed direct comparison between ⁶⁷Ga and ¹¹¹In (1MBq) in causing DNA damage, including the effect of chelators (EDTA and DTPA) and the effects of a free radical scavenger (DMSO). The cytotoxicity of internalized (by means of delivery in the form of oxine complexes) and non-internalized ⁶⁷Ga and ¹¹¹In was measured in DU145 prostate cancer cells after a one-hour incubation using cell viability (

SUBMITTER: Othman MF 

PROVIDER: S-EPMC5303015 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature