Leishmania infection inhibits macrophage motility by altering F-actin dynamics and the expression of adhesion complex proteins.

ABSTRACT: Leishmania is an intracellular protozoan parasite that causes a broad spectrum of clinical manifestations, ranging from self-healing skin lesions to fatal visceralizing disease. As the host cells of choice for all species of Leishmania, macrophages are critical for the establishment of infections. How macrophages contribute to parasite homing to specific tissues and how parasites modulate macrophage function are still poorly understood. In this study, we show that Leishmania amazonensis infection inhibits macrophage roaming motility. The reduction in macrophage speed is not dependent on particle load or on factors released by infected macrophages. L. amazonensis-infected macrophages also show reduced directional migration in response to the chemokine MCP-1. We found that infected macrophag

SUBMITTER: de Menezes JP 

PROVIDER: S-EPMC5303118 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature