Lymphangiogenesis in rat asthma model.

ABSTRACT: Although bronchial angiogenesis has been well documented in allergic asthma, lymphangiogenesis has not been widely studied. Therefore, we evaluated changes in lung lymphatics in a rat model of allergen-induced asthma using house dust mite (Der p 1; 100 μg/challenge). Additionally, properties of isolated lung lymphatic endothelial cells (CD45^-, CD141⁺, LYVE-1⁺, Prox-1⁺) were studied in vitro. Three weeks after the onset of intranasal allergen exposure (twice-weekly), an increase in the number of lung lymphatic vessels was measured (34% increase) by lung morphometry. New lymphatic structures were seen predominantly in the peribronchial and periarterial interstitial space but also surrounding large airways. Isolated lymphatic endothelial cells from

SUBMITTER: Moldobaeva A 

PROVIDER: S-EPMC5303156 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature