Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization.

ABSTRACT: Chemokines control the migration of cells in normal physiological processes and in the context of disease such as inflammation, autoimmunity and cancer. Two major interactions are involved: (i) binding of chemokines to chemokine receptors, which activates the cellular machinery required for movement; and (ii) binding of chemokines to glycosaminoglycans (GAGs), which facilitates the organization of chemokines into haptotactic gradients that direct cell movement. Chemokines can bind and activate their receptors as monomers; however, the ability to oligomerize is critical for the function of many chemokines in vivo Chemokine oligomerization is thought to enhance their affinity for GAGs, and here we show that it significantly affects the ability of chemokines to accumulate on and be retained b

SUBMITTER: Dyer DP 

PROVIDER: S-EPMC5303277 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature