Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.

ABSTRACT: Heterogeneous ribonucleoprotein A1 (hnRNP A1) is crucial for regulating alternative splicing. Its integrated function within an organism has not, however, been identified. We generated hnRNP A1 knockout mice to study the role of hnRNP A1 in vivo The knockout mice, hnRNP A1^-/-, showed embryonic lethality because of muscle developmental defects. The blood pressure and heart rate of the heterozygous mice were higher than those of the wild-type mice, indicating heart function defects. We performed mouse exon arrays to study the muscle development mechanism. The processes regulated by hnRNP A1 included cell adhesion and muscle contraction. The expression levels of muscle development-related genes in hnRNP A1^+/- mice were significantly different from those in wild-type mice

SUBMITTER: Liu TY 

PROVIDER: S-EPMC5303281 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature