Inhibition of glioblastoma dispersal by the MEK inhibitor PD0325901.

ABSTRACT:

Background

Dispersal of glioblastoma (GBM) cells leads to recurrence and poor prognosis. Accordingly, molecular pathways involved in dispersal are potential therapeutic targets. The mitogen activated protein kinase/extracellular signal regulated kinase (MAPK/ERK) pathway is commonly dysregulated in GBM, and targeting this pathway with MEK inhibitors has proven effective in controlling tumor growth. Since this pathway also regulates ECM remodeling and actin organization - processes crucial to cell adhesion, substrate attachment, and cell motility - the aim of this study was to determine whether inhibiting this pathway could also impede dispersal.

Methods

A variety of methods were used to quantify the effects of the MEK inhibitor, PD0325901, on potential regulators of dispersa

SUBMITTER: Shannon S 

PROVIDER: S-EPMC5303286 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature