Sex-based differential regulation of bacterial-induced bone resorption.

ABSTRACT:

Background and objective

Periodontal disease pathogenesis is comprised of the complex inflammatory immune response to oral bacterial dysbiosis. Like other inflammatory diseases, there is sexual dimorphism evident in periodontal diseases. During periodontitis, inflammatory chemokines direct neutrophils to migrate to the site of infection to neutralize the pathogen. Interestingly, these same chemokines are also involved in regulating pathogen-induced osteoclast formation. Previous reports show differences in bone turnover and lymphocyte recruitment between sexes. We hypothesize that chemokine expression is differentially regulated by sex and thus results in differential osteoclast formation.

Material and methods

Male and female mice were utilized to isolate neutrophils based o

SUBMITTER: Valerio MS 

PROVIDER: S-EPMC5303566 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature