Rapid simultaneous high-resolution mapping of myelin water fraction and relaxation times in human brain using BMC-mcDESPOT.

ABSTRACT: A number of central nervous system (CNS) diseases exhibit changes in myelin content and magnetic resonance longitudinal, T₁, and transverse, T₂, relaxation times, which therefore represent important biomarkers of CNS pathology. Among the methods applied for measurement of myelin water fraction (MWF) and relaxation times, the multicomponent driven equilibrium single pulse observation of T₁ and T₂ (mcDESPOT) approach is of particular interest. mcDESPOT permits whole brain mapping of multicomponent T₁ and T₂, with data acquisition accomplished within a clinically realistic acquisition time. Unfortunately, previous studies have indicated the limited performance of mcDESPOT in the setting of the modest signal-to-noise range of hi

SUBMITTER: Bouhrara M 

PROVIDER: S-EPMC5303643 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature