IL-10-Producing CD1d^hiCD5⁺ Regulatory B Cells May Play a Critical Role in Modulating Immune Homeostasis in Silicosis Patients.

ABSTRACT: Silicosis is characterized by chronic lung inflammation and fibrosis, which are extremely harmful to human health. The pathogenesis of silicosis involves uncontrolled immune processes. Evidence supports that regulatory B cells (Bregs) produce negative regulatory cytokines, such as IL-10, which can negatively regulate immune responses in inflammation and autoimmune diseases. Our previous study found that IL-10-producing B cells were involved in the development of silica-induced lung inflammation and fibrosis of mice. However, little is known about the role of Bregs in silicosis patients (SP). In this study, we found that serum concentrations of IL-10 were significantly increased in SP by using protein array screening. We further determined that the frequency of IL-10-producing CD1d^hi</

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5303715 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature