Increased anterior cingulate cortex response precedes behavioural adaptation in anorexia nervosa.

ABSTRACT: Patients with anorexia nervosa (AN) are characterised by increased self-control, cognitive rigidity and impairments in set-shifting, but the underlying neural mechanisms are poorly understood. Here we used functional magnetic resonance imaging (fMRI) to elucidate the neural correlates of behavioural adaptation to changes in reward contingencies in young acutely ill AN patients. Thirty-six adolescent/young adult, non-chronic female AN patients and 36 age-matched healthy females completed a well-established probabilistic reversal learning task during fMRI. We analysed hemodynamic responses in empirically-defined regions of interest during positive feedback and negative feedback not followed/followed by behavioural adaptation and conducted functional connectivity analyses. Although overall ta

SUBMITTER: Geisler D 

PROVIDER: S-EPMC5304157 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature