Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes.

ABSTRACT: Chloride is the most abundant permeable anion in the cell, and numerous studies in the last two decades highlight the great importance and broad physiological role of chloride currents mediated anion transport. They participate in a multiplicity of key processes, as for instance, the regulation of electrical excitability, apoptosis, cell cycle, epithelial secretion and neuronal excitability. In addition, dysfunction of Cl^- channels is involved in a variety of human diseases such as epilepsy, osteoporosis and different cancer types. Historically, chloride channels have been of less interest than the cation channels. In fact, there seems to be practically no quantitative studies of the dynamics of chloride currents. Here, for the first time, we have quantitatively studied experime

SUBMITTER: M De la Fuente I 

PROVIDER: S-EPMC5304176 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature