Novel ¹⁸F-Labeled 1-Hydroxyanthraquinone Derivatives for Necrotic Myocardium Imaging.

ABSTRACT: Rapid detection and precise evaluation of myocardial viability is necessary to aid in clinical decision making whether to recommend revascularization for patients with myocardial infarction (MI). Three novel ¹⁸F-labeled 1-hydroxyanthraquinone derivatives were synthesized, characterized, and evaluated as potential necrosis avid imaging agents for assessment of myocardial viability. Among these tracers, [¹⁸F]FA3OP emerged as the most promising compound with best stability and highest targetability. Clear PET images of [¹⁸F]FA3OP were obtained in rat model of myocardial infarction and reperfusion at 1 h after injection. In addition, the possible mechanisms of [¹⁸F]FA3OP for necrotic myocardium were discussed. The results showed [¹⁹F]FA3OP

SUBMITTER: Ji AY 

PROVIDER: S-EPMC5304286 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature