An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis.

ABSTRACT: Medical responders to radiological and nuclear disasters currently lack sufficient high-throughput and minimally invasive biodosimetry tools to assess exposure and injury in the affected populations. For this reason, we have focused on developing robust radiation exposure biomarkers in easily accessible biofluids such as urine, serum and feces. While we have previously reported on urine and serum biomarkers, here we assessed perturbations in the fecal metabolome resulting from exposure to external X radiation in vivo. The gastrointestinal (GI) system is of particular importance in radiation biodosimetry due to its constant cell renewal and sensitivity to radiation-induced injury. While the clinical GI symptoms such as pain, bloating, nausea, vomiting and diarrhea are manifested after radia

SUBMITTER: Goudarzi M 

PROVIDER: S-EPMC5304359 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature