How can functional annotations be derived from profiles of phenotypic annotations?

ABSTRACT:

Background

Loss-of-function phenotypes are widely used to infer gene function using the principle that similar phenotypes are indicative of similar functions. However, converting phenotypic to functional annotations requires careful interpretation of phenotypic descriptions and assessment of phenotypic similarity. Understanding how functions and phenotypes are linked will be crucial for the development of methods for the automatic conversion of gene loss-of-function phenotypes to gene functional annotations.

Results

We explored the relation between cellular phenotypes from RNAi-based screens in human cells and gene annotations of cellular functions as provided by the Gene Ontology (GO). Comparing different similarity measures, we found that information content-based measures

SUBMITTER: Serrano-Solano B 

PROVIDER: S-EPMC5304448 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature