Acute plasma tau relates to prolonged return to play after concussion.

ABSTRACT:

Objective

To determine whether tau changes after sport-related concussion (SRC) relate to return to play (RTP).

Methods

Collegiate athletes underwent preseason plasma sampling and cognitive testing and were followed. After a SRC (n = 46), athletes and controls (n = 37) had sampling at 6 hours, and at 24 hours, 72 hours, and 7 days after SRC. A sample of 21 nonathlete controls were compared at baseline. SRC athletes were grouped by long (>10 days, n = 23) and short (≤10 days, n = 18) RTP. Total tau was measured using an ultrasensitive immunoassay.

Results

Both SRC and athlete controls had significantly higher mean tau at baseline compared to nonathlete healthy controls (F_101,3 = 19.644, p < 0.01). Compared to SRC athletes with short RTP, those with long RTP

SUBMITTER: Gill J 

PROVIDER: S-EPMC5304458 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature