Vascular risk factors in INPH: A prospective case-control study (the INPH-CRasH study).

ABSTRACT:

Objective

To assess the complete vascular risk factor (VRF) profile of idiopathic normal pressure hydrocephalus (INPH) using a large sample of representative patients with INPH and population-based controls to determine the extent to which vascular disease influences INPH pathophysiology.

Methods

All patients with INPH who underwent shunting in Sweden in 2008-2010 were compared to age- and sex-matched population-based controls. Inclusion criteria were age 60-85 years and no dementia. The 10 most important VRFs and cerebrovascular and peripheral vascular disease were prospectively assessed using blood samples, clinical examinations, and standardized questionnaires. Assessed VRFs were hypertension, hyperlipidemia, diabetes, obesity, psychosocial factors, smoking habits, diet,

SUBMITTER: Israelsson H 

PROVIDER: S-EPMC5304464 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature