Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles.

ABSTRACT:

Background

Concerns have been expressed that inhaled nanoparticles may behave differently to larger particles in terms of lung clearance and translocation, with potential implications for their toxicity. Studies undertaken to investigate this have typically involved limited post-exposure periods. There is a shortage of information on longer-term clearance and translocation patterns and their dependence on particle size, which this study aimed to address.

Methods

Rats were exposed (<3 h) nose-only to aerosols of spark-generated radioactive iridium-192 nanoparticles of four sizes: 10 nm, 15 nm, 35 nm and 75 nm (count median diameter) (aerosol mass concentrations 17, 140, 430, and 690 μg/m³, respectively). The content of iridium-192 in the whole animal, organs, tissu

SUBMITTER: Buckley A 

PROVIDER: S-EPMC5304551 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature