Site-selective Suzuki-Miyaura coupling of heteroaryl halides - understanding the trends for pharmaceutically important classes.

ABSTRACT: Suzuki-Miyaura cross-coupling reactions of heteroaryl polyhalides with aryl boronates are surveyed. Drawing on data from literature sources as well as bespoke searches of Pfizer's global chemistry RKB and CAS Scifinder® databases, the factors that determine the site-selectivity of these reactions are discussed with a view to rationalising the trends found.

SUBMITTER: Almond-Thynne J 

PROVIDER: S-EPMC5304707 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature