Risk factors associated with iatrogenic opioid and benzodiazepine withdrawal in critically ill pediatric patients: a systematic review and conceptual model.

ABSTRACT:

Objectives

Analgesia and sedation are common therapies in pediatric critical care, and rapid titration of these medications is associated with iatrogenic withdrawal syndrome. We performed a systematic review of the literature to identify all common and salient risk factors associated with iatrogenic withdrawal syndrome and build a conceptual model of iatrogenic withdrawal syndrome risk in critically ill pediatric patients.

Data sources

Multiple databases, including PubMed/Medline, EMBASE, CINAHL, and the Cochrane Central Registry of Clinical Trials, were searched using relevant terms from January 1, 1980, to August 1, 2014.

Study selection

Articles were included if they were published in English and discussed iatrogenic withdrawal syndrome following either opioid or b

SUBMITTER: Best KM 

PROVIDER: S-EPMC5304939 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature