Transferrin receptor-targeted pH-sensitive micellar system for diminution of drug resistance and targetable delivery in multidrug-resistant breast cancer.

ABSTRACT: The emergence of drug resistance is partially associated with overproduction of transferrin receptor (TfR). To overcome multidrug resistance (MDR) and achieve tumor target delivery, we designed a novel biodegradable pH-sensitive micellar system modified with HAIYPRH, a TfR ligand (7pep). First, the polymers poly(l-histidine)-coupled polyethylene glycol-2000 (PHIS-PEG₂₀₀₀) and 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (7pep-DSPE-PEG₂₀₀₀) were synthesized, and the mixed micelles were prepared by blending of PHIS-PEG₂₀₀₀ and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (DSPE-PEG₂₀₀₀) or 7pep-DSPE-PEG₂₀₀₀ (7-pep HD micelles). The micelles exhibited good size uniformit

SUBMITTER: Gao W 

PROVIDER: S-EPMC5304995 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature