The influence of propoxyphene withdrawal on opioid use in veterans.

ABSTRACT:

Purpose

Our aim is to determine if propoxyphene withdrawal from the US market was associated with opioid continuation, continued chronic opioid use, and secondary propoxyphene-related adverse events (emergency department visits, opioid-related events, and acetaminophen toxicity).

Methods

Medical service use and pharmacy data from 19/11/08 to 19/11/11 were collected from the national Veterans Healthcare Administration healthcare databases. A quasi-experimental pre-post retrospective cohort design utilizing a historical comparison group provided the study framework. Logistic regression controlling for baseline covariates was used to estimate the effect of propoxyphene withdrawal.

Results

There were 24,328 subjects (policy affected n = 10,747; comparison n = 13,581) meet

SUBMITTER: Hayes CJ 

PROVIDER: S-EPMC5305002 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature