Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.

ABSTRACT:

Background

Anorexia nervosa (AN) and body dysmorphic disorder (BDD) frequently co-occur, and have several overlapping phenomenological features. Little is known about their shared neurobiology. The aim of the study was to compare modular organization of brain structural connectivity.

Method

We acquired diffusion-weighted magnetic resonance imaging data on unmedicated individuals with BDD (n = 29), weight-restored AN (n = 24) and healthy controls (HC) (n = 31). We constructed connectivity matrices using whole-brain white matter tractography, and compared modular structures across groups.

Results

AN showed abnormal modularity involving frontal, basal ganglia and posterior cingulate nodes. There was a trend in BDD for similar abnormalities, but no significant differences

SUBMITTER: Zhang A 

PROVIDER: S-EPMC5305274 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature