Associations Between β-Amyloid Kinetics and the β-Amyloid Diurnal Pattern in the Central Nervous System.

ABSTRACT:

Importance

Recent studies found that the concentration of amyloid-β (Aβ) fluctuates with the sleep-wake cycle. Although the amplitude of this day/night pattern attenuates with age and amyloid deposition, to our knowledge, the association of Aβ kinetics (ie, production, turnover, and clearance) with this oscillation has not been studied.

Objective

To determine the association between Aβ kinetics, age, amyloid levels, and the Aβ day/night pattern in humans.

Design, setting, and participants

We measured Aβ concentrations and kinetics in 77 adults aged 60 to 87 years with and without amyloid deposition by a novel precise mass spectrometry method at the Washington University School of Medicine in St Louis, Missouri. We compared findings of 2 orthogonal methods, enzyme-link

SUBMITTER: Lucey BP 

PROVIDER: S-EPMC5305432 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature