Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster.

ABSTRACT: Food consumption is an essential component of animal fitness; however, excessive food intake in humans increases risk for many diseases. The roles of neuroendocrine feedback loops, food sensing modalities, and physiological state in regulating food intake are well understood, but not the genetic basis underlying variation in food consumption. Here, we applied ten generations of artificial selection for high and low food consumption in replicate populations of Drosophila melanogaster. The phenotypic response to selection was highly asymmetric, with significant responses only for increased food consumption and minimal correlated responses in body mass and composition. We assessed the molecular correlates of selection responses by DNA and RNA sequencing of the selection lines. The high and lo

SUBMITTER: Garlapow ME 

PROVIDER: S-EPMC5305434 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature