Compressive loading of the murine tibia reveals site-specific micro-scale differences in adaptation and maturation rates of bone.

ABSTRACT: Loading increases bone mass and strength in a site-specific manner; however, possible effects of loading on bone matrix composition have not been evaluated. Site-specific structural and material properties of mouse bone were analyzed on the macro- and micro/molecular scale in the presence and absence of axial loading. The response of bone to load is heterogeneous, adapting at molecular, micro-, and macro-levels.

Introduction

Osteoporosis is a degenerative disease resulting in reduced bone mineral density, structure, and strength. The overall aim was to explore the hypothesis that changes in loading environment result in site-specific adaptations at molecular/micro- and macro-scale in mouse bone.

Methods

Right tibiae of adult mice were subjected to well-defined cyclic axial lo

SUBMITTER: Bergstrom I 

PROVIDER: S-EPMC5306148 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature