Effect of Endoscopic Gastroplication on the Genome-Wide Transcriptome in the Upper Gastrointestinal Tract.

ABSTRACT:

Background

Bariatric surgery is an effective intervention strategy in obesity, resulting in sustained weight loss and a reduction of comorbidities. Gastroplication, using the articulating circular endoscopic stapler, was recently introduced as a transoral bariatric technique. This procedure reduces gastric volume and induced 34.9 % of excess weight loss in the first year (Paulus et al. Gastrointest Endosc. 81(2):312-20, 3). The aim of the present study was to gain insight in the long-term effects and underlying mechanisms of gastroplication by investigating differences in the genome-wide gastric and duodenal transcriptome before and 1 year after intervention.

Methods

Ten morbidly obese patients (BMI 39.8 ± 0.9 kg/m² (mean ± SEM)) underwent gastroplication. Previou

SUBMITTER: van der Wielen N 

PROVIDER: S-EPMC5306242 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature