Influence of pH, particle size and crystal form on dissolution behaviour of engineered nanomaterials.

ABSTRACT: Solubility is a critical component of physicochemical characterisation of engineered nanomaterials (ENMs) and an important parameter in their risk assessments. Standard testing methodologies are needed to estimate the dissolution behaviour and biodurability (half-life) of ENMs in biological fluids. The effect of pH, particle size and crystal form on dissolution behaviour of zinc metal, ZnO and TiO₂ was investigated using a simple 2 h solubility assay at body temperature (37 °C) and two pH conditions (1.5 and 7) to approximately frame the pH range found in human body fluids. Time series dissolution experiments were then conducted to determine rate constants and half-lives. Dissolution characteristics of investigated ENMs were compared with those of their bulk analogues for both p

SUBMITTER: Avramescu ML 

PROVIDER: S-EPMC5306302 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature