Adjustment for tobacco smoking and alcohol consumption by simultaneous analysis of several types of cancer.

ABSTRACT:

Purpose

Tobacco smoking and alcohol consumption are risk factors for several types of cancer and may act as confounders in aetiological studies. Large register-based cohorts often lack data on tobacco and alcohol. We present a method for computing estimates of cancer risk adjusted for tobacco and alcohol without exposure information.

Methods

We propose the use of confirmatory factor analysis models for simultaneous analysis of several cancer sites related to tobacco and alcohol. In the analyses, the unobserved pattern of smoking habits and alcohol drinking is considered latent common factors. The models allow for different effects on each cancer site, and also for appropriate latent site-specific factors for subgroup variation. Results may be used to compute expected numbers

SUBMITTER: Haldorsen T 

PROVIDER: S-EPMC5306353 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature