Age-Dependent Association of TNFSF15/TNFSF8 Variants and Leprosy Type 1 Reaction.

ABSTRACT: A current major challenge in leprosy control is the prevention of permanent disabilities. Host pathological inflammatory responses termed type 1 reaction (T1R) are a leading cause of nerve damage for leprosy patients. The environmental or inherited factors that predispose leprosy cases to undergo T1R are not known. However, studies have shown an important contribution of host genetics for susceptibility to T1R. We have previously identified variants encompassing the TNFSF15/TNFSF8 genes as T1R risk factors in a Vietnamese sample and replicated this association in a Brazilian sample. However, we failed to validate in Brazilian patients the strong association of TNFSF15/TNFSF8 markers rs6478108 and rs7863183 with T1R that we had observed in Vietnamese patients. He

SUBMITTER: Fava VM 

PROVIDER: S-EPMC5306391 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature