An original pharmacoepidemiological-pharmacodynamic method: application to antipsychotic-induced movement disorders.

ABSTRACT:

Aims

Pharmacovigilance databases are usually used to detect new potential signals that are relevant for drug safety. They are seldom used for explanatory purposes, e.g. to understand the mechanisms of adverse drug reactions (ADRs). The aim of the present study was to combine pharmacovigilance and pharmacodynamic data to investigate the association between dopamine D2, serotonin 5HT2A, and muscarinic M1 receptor occupancy and the risks of antipsychotic drug (AP)-induced movement disorders.

Methods

First, we performed a case-noncase analysis using spontaneous reports from the World Health Organization (WHO) Global Individual Case Safety Report (ICSR) database, VigiBase®. We thus measured the risk of reporting movement disorders compared with all other ADRs [expressed as a repo

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC5306476 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature