The effect of renal dysfunction and haemodialysis on circulating liver specific miR-122.

ABSTRACT:

Aims

microRNA-122 (miR-122) is a hepatotoxicity biomarker with utility in the management of paracetamol overdose and in drug development. Renal dysfunction and haemodialysis have been associated with a reduction in circulating microRNA. The objective of this study was to determine their effect on miR-122.

Methods

Blood samples were collected from 17 patients with end-stage renal disease (ESRD) on haemodialysis, 22 healthy controls, 30 patients with chronic kidney disease (CKD) and 15 patients post-kidney transplantation. All had normal standard liver function tests. Samples from ESRD patients were collected immediately pre- and post-haemodialysis. Serum alanine transaminase activity (ALT), miR-122 and miR-885 (liver enriched) were compared.

Results

Circulating miR-122

SUBMITTER: Rivoli L 

PROVIDER: S-EPMC5306495 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature