Population pharmacokinetics of daptomycin in adult patients undergoing continuous renal replacement therapy.

ABSTRACT:

Aim

The objective of this population pharmacokinetic (PK) analysis was to provide guidance for the dosing interval of daptomycin in patients undergoing continuous renal replacement therapy (CRRT).

Methods

A previously published population PK model for daptomycin was updated with data from patients undergoing continuous veno-venous haemodialysis (CVVHD; n = 9) and continuous veno-venous haemodiafiltration (CVVHDF; n = 8). Model-based simulations were performed to compare the 24 h AUC, C_max and C_min of daptomycin following various dosing regimens (4, 6, 8, 10, and 12 mg kg^-1 every [Q] 24 h and Q48 h), with the safety and efficacy exposure references for Staphylococcus aureus bacteraemia/right-sided infective endocarditis.

Results

The pre

SUBMITTER: Xu X 

PROVIDER: S-EPMC5306496 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature