Quantitative Tissue Spectroscopy of Near Infrared Fluorescent Nanosensor Implants.

ABSTRACT: Implantable, near infrared (nIR) fluorescent nanosensors are advantageous for in vivo monitoring of biological analytes since they can be rendered selective for a particular target molecule while utilizing their unique optical properties and the nIR tissue transparency window for information transfer without an internal power source or telemetry. However, basic questions remain regarding the optimal encapsulation platform, geometrical properties, and concentration ranges required for high signal to noise ratio and effective detection through biological tissue. In this work, we systematically explore these variables quantitatively to optimize the performance of such optical nanosensors for biomedical applications. We investigate both alginate and polyethylene glycol (PEG) as model hydrogel

SUBMITTER: Iverson NM 

PROVIDER: S-EPMC5307332 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature