Hematopoietic pannexin 1 function is critical for neuropathic pain.

ABSTRACT: Neuropathic pain symptoms respond poorly to available therapeutics, with most treated patients reporting unrelieved pain and significant impairment in daily life. Here, we show that Pannexin 1 (Panx1) in hematopoietic cells is required for pain-like responses following nerve injury in mice, and a potential therapeutic target. Panx1 knockout mice (Panx1^-/-) were protected from hypersensitivity in two sciatic nerve injury models. Bone marrow transplantation studies show that expression of functional Panx1 in hematopoietic cells is necessary for mechanical hypersensitivity following nerve injury. Reconstitution of irradiated Panx1 knockout mice with hematopoietic Panx1^-/- cells engineered to re-express Panx1 was sufficient to recover hypersensitivity after nerve injury;

SUBMITTER: Weaver JL 

PROVIDER: S-EPMC5307344 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature