Psychological stress and risk of incident atrial fibrillation in men and women with known atrial fibrillation genetic risk scores.

ABSTRACT: Psychological stress has been reported as a possible trigger of atrial fibrillation (AF). No studies have investigated whether any association between stress and AF could be modified by genetic susceptibility to AF (AF-genetic risk score (AF-GRS)). 8765 men and 13,543 women from the Malmö Diet Cancer Study, a population-based cohort, were included in the analyses. A variable representing stress was constructed from questions measuring job strain, and from one question assessing non-occupational stress. Cox proportional hazards regression models were adjusted for known covariates of AF. Mean follow-up times and number of recorded incident AF were 14.2 years and 1116 events for men, and 15.1 years and 932 events for women. Among women, high stress was associated with AF in the age adjusted m

SUBMITTER: Svensson T 

PROVIDER: S-EPMC5307347 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature