Copeptin for risk stratification in non-traumatic headache in the emergency setting: a prospective multicenter observational cohort study.

ABSTRACT:

Background

In the emergency setting, non-traumatic headache is a benign symptom in 80% of cases, but serious underlying conditions need to be ruled out. Copeptin improves risk stratification in several acute diseases. Herein, we investigated the value of copeptin to discriminate between serious secondary headache and benign headache forms in the emergency setting.

Methods

Patients presenting with acute non-traumatic headache were prospectively enrolled into an observational cohort study. Copeptin was measured upon presentation to the emergency department. Primary endpoint was serious secondary headache defined by a neurologic cause requiring immediate treatment of the underlying disease. Secondary endpoint was the combination of mortality and hospitalization within 3 months.

SUBMITTER: Blum CA 

PROVIDER: S-EPMC5307398 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature