CD4 T-cell cytokines synergize to induce proliferation of malignant and nonmalignant innate intraepithelial lymphocytes.

ABSTRACT: Refractory celiac disease type II (RCDII) is a severe complication of celiac disease (CD) characterized by the presence of an enlarged clonal population of innate intraepithelial lymphocytes (IELs) lacking classical B-, T-, and natural killer (NK)-cell lineage markers (Lin^-IELs) in the duodenum. In ∼50% of patients with RCDII, these Lin^-IELs develop into a lymphoma for which no effective treatment is available. Current evidence indicates that the survival and expansion of these malignant Lin^-IELs is driven by epithelial cell-derived IL-15. Like CD, RCDII is strongly associated with HLA-DQ2, suggesting the involvement of HLA-DQ2-restricted gluten-specific CD4⁺ T cells. We now show that gluten-specific CD4⁺ T cells isolated from CD duode

SUBMITTER: Kooy-Winkelaar YM 

PROVIDER: S-EPMC5307453 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature