Independent active and thermodynamic processes govern the nucleolus assembly in vivo.

ABSTRACT: Membraneless organelles play a central role in the organization of protoplasm by concentrating macromolecules, which allows efficient cellular processes. Recent studies have shown that, in vitro, certain components in such organelles can assemble through phase separation. Inside the cell, however, such organelles are multicomponent, with numerous intermolecular interactions that can potentially affect the demixing properties of individual components. In addition, the organelles themselves are inherently active, and it is not clear how the active, energy-consuming processes that occur constantly within such organelles affect the phase separation behavior of the constituent macromolecules. Here, we examine the phase separation model for the formation of membraneless organelles in vivo by ass

SUBMITTER: Falahati H 

PROVIDER: S-EPMC5307486 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature