Involvement of fatty acid synthase in dengue virus infection.

ABSTRACT:

Background

The mosquito transmitted Dengue virus (DENV) remains a significant public health problem in many tropical and subtropical countries. Increasing evidence has suggested that during the infection process cellular lipids play important roles at several stages of the replication cycle. This study sought to characterize the changes in lipid metabolism gene expression and investigated the role of one enzyme, fatty acid synthase, in DENV infection.

Methods

Transcriptional profiles of genes associated with lipid metabolism were evaluated by real-time PCR after infection of different cell lines (HepG2 and HEK293T/17) and with different DENVs (laboratory adapted and low passage). Expression profiles of genes were evaluated by western blotting. A critical lipid metabolism pro

SUBMITTER: Tongluan N 

PROVIDER: S-EPMC5307738 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature